CONVERGENT SYNTHETIC METHODOLOGY FOR THE CONSTRUCTION OF SELF-ADJUVANTING LIPOPEPTIDE VACCINES USING A NOVEL CARBOHYDRATE SCAFFOLD

Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold

A novel convergent synthetic strategy for the construction of multicomponent self-adjuvanting lipopeptide vaccines was developed.A tetraalkyne-functionalized glucose derivative and lipidated Fmoc-lysine were prepared by Earrings novel efficient and convenient syntheses.The carbohydrate building block was coupled to the self-adjuvanting lipidic moie

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